Endocrine Abstracts

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare tumors that arise from the neuroendocrine tissue along the paravertebral axis with the ability to secrete cathecolamines. Up to 33% of these tumors may be hereditary either alone or as a component of a multiple tumor syndrome. Germline SDHA mutations are relatively frequent (7.6%) in patients with genetically unexplained PGL, even in the absence of familial or clinical indications for inherited PGL....